Molecular Infectious Tests


Over the past decade, there has been an explosion in the use of molecular infectious disease test in Ahmedabad to diagnose and manage infectious diseases. HIV is a prime example of an infectious agent whose diagnosis at least in the acute stage, susceptibility testing, and management are all dependent on molecular diagnostics. The ability to accurately diagnose a plethora of respiratory pathogens quickly, simply, and relatively inexpensively compared to traditional methods is becoming a reality. Direct sequencing and microarray analysis hold great promise for directly detecting a wide variety of organisms from clinical specimens. The question is where this testing should be done in the clinical laboratory. There are at least four models that have emerged:

  • Molecular infectious disease testing as an arm of the clinical microbiology laboratory
  • Molecular infectious disease testing is done in a central molecular pathology laboratory under the leadership of a clinical microbiologist
  • Molecular infectious disease testing is done in a central molecular pathology laboratory under the leadership of an individual whose primary interest is in another area of molecular pathology
  • Molecular infectious disease testing is sent to a reference laboratory and not done on-site or within the institution’s health care system.

We have asked three individuals who have thought about this very complex issue to share their rationale for supporting one of these models. Frederick Nolte is the Director of Clinical Laboratories and Director of Molecular Pathology at the Medical University of South Carolina, is active in and held several positions of responsibility in AMP (Association of Molecular Pathology), and is Chair of the CLSI’s Area Committee for Molecular Methods, Alex McAdam is the Director of the Infectious Diseases Diagnostic Division at Children’s Hospital Boston and an editor of this journal, and his colleague, Nima Mosammaparast, is the Assistant Director of the Infectious Diseases Diagnostic Laboratory at Children’s Hospital Boston.

HPV-LBC Screening Test

Liquid Based Cytology (LBC) is a new technique for collecting cytological samples in order to detect cervical cancer.

HCV Genotyping

A genotype is a way to put the hepatitis C virus (HCV) into categories based on similar genes. It’s important to know and understand HCV genotypes.

HBV DNA Quantitative PCR

HBV DNA quantitation is used extensively world wide for the diagnosis and monitoring of treatment of Hepatitis B virus (HBV) infection.